The Role

This is an exciting role at BenevolentAI where you will apply your experience as an in vivo pharmacologist and project representative to help projects drive to achieve key milestones. As a member of a dynamic, multi-disciplinary team of scientists passionate about developing medicines, you will lead a team of project representatives and also act as project rep for projects, defining the translational strategy with in vivo PD models and target engagement.

Working collaboratively with DMPK, clinical pharmacology, modelling, In vivo and In vitro colleagues, using your theoretical and practical expertise, you’ll take a hands-on approach in the externalised development of disease models, and management of studies across the portfolio. You will supplement the analysis of results through histology, molecular and biochemical profiling. You will identify and build strong relationships with the best CROs to deliver the appropriate support for projects, build systems and deliver datasets that will have a direct impact on project progression.

Primary Responsibilities:

• Build and lead a team of in-vivo biologists that provide expert in-vivo recommendations and implementation of said recommendations on all aspects of in-vivo biology, ultimately supporting the translational strategy through key stage gates for all BAI drug discovery programs
• Within the project team, serve as a scientific expert contributing at a high level across in vivo pharmacology activities, including supporting PKPD, translational efficacy models, TE and biomarker strategy, study design, implementation and interpretation.
• Developing a deep understanding of disease mechanisms and target biology, participating in broader project strategy and decision making.
• With a comprehensive understanding of all aspects of study design and implementation, you will be responsible for establishing strong cross-functional relationships with PK/PD and TE stakeholders, resulting in cohesion and clarity in the delivery of studies and the presentation of decision-making data.
• Where required, coordinating in vivo studies in multiple projects across the portfolio to ensure high quality, efficiency and timely delivery of studies whether external or internal.
• You will also have the opportunity to work with other In Vivo project reps to support target identification disease deployments.

Additional Responsibilities:

• As a key part of project teams, you’ll have the opportunity to work closely with others from areas such as AI/machine learning, medicinal chemistry, DMPK and in vitro pharmacology to help design and coordinate study designs and experimental plans.

We are looking for someone with:

• PhD or Degree qualified with extensive experience in working in a vivarium and leading in vivo research activities.
• Significant experience working as a functional lead on project teams , ideally to preclinical development and with experience writing reports and documentation to support regulatory filing.
• Demonstrated experience in successfully leading and developing teams.
• Experience of working closely with PK/PD and in vitro biology leads within project environments, and ideally with a good understanding of drug delivery and PK in relation to PD.
• An in-depth understanding of a therapy area such as neuroscience, oncology, metabolic diseases, drug safety etc would be valuable.
• Current or previous Personal Home Office Licence holder (modules 1-4/A-C, with Module 5 being desirable)
• A good understanding of integrated physiology, pathophysiology and in vivo practice and procedures. Wide-ranging experience in designing, directing and implementing in vivo experiments to respond to key research and pharmacodynamic questions
• Track record of significant contributions to achievement of important scientific decisions or milestones on projects.
• Experience of working with external KOL and/or CROs desirable
• Excellent communication skill